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Uveitis: Inflammation of the Uvea and Associated Complications

Uveitis refers to the inflammation of the uvea, the middle layer of the eye, which includes the iris, ciliary body, and choroid. This condition can cause significant discomfort and vision problems, and if left untreated, it can lead to serious complications. Understanding the causes, symptoms, and potential complications of uveitis is crucial for effective management and treatment.


What is Uveitis?
Uveitis is an umbrella term for a group of inflammatory diseases that produce swelling and destroy eye tissues. The uvea consists of three parts:

  1. Iris: The colored part of the eye.

  2. Ciliary Body: The part of the eye that releases the clear liquid in the eye.

  3. Choroid: The layer of blood vessels and connective tissue between the sclera (white of the eye) and the retina.


Uveitis can affect one or both eyes and can occur at any age. It is classified into different types based on the part of the uvea affected:

  • Anterior Uveitis: Inflammation of the iris (iritis) or the iris and ciliary body (iridocyclitis).

  • Intermediate Uveitis: Inflammation of the ciliary body (cyclitis) and the vitreous (vitritis).

  • Posterior Uveitis: Inflammation of the choroid (choroiditis), retina (retinitis), or both (chorioretinitis).

  • Panuveitis: Inflammation affecting all parts of the uvea.

Causes of Uveitis
The exact cause of uveitis is often unknown, but it can be associated with a variety of factors, including:


1. Autoimmune and Inflammatory Diseases

  • Conditions such as rheumatoid arthritis, lupus, and ankylosing spondylitis can cause uveitis.

  • Sarcoidosis, an inflammatory disease that affects multiple organs, including the eyes.


2. Infections

  • Bacterial Infections: Tuberculosis, syphilis, and Lyme disease.

  • Viral Infections: Herpes simplex, herpes zoster, and cytomegalovirus.

  • Parasitic Infections: Toxoplasmosis.

  • Fungal Infections: Histoplasmosis.


3. Eye Injuries

  • Trauma to the eye can lead to uveitis.


4. Genetic Factors

  • Certain genetic markers, such as HLA-B27, are associated with an increased risk of developing uveitis.


5. Idiopathic

  • In many cases, the exact cause of uveitis cannot be determined and is considered idiopathic.



Symptoms of Uveitis
The symptoms of uveitis can vary depending on the type and severity of the inflammation. Common symptoms include:

  • Eye Redness: Inflammation can cause redness in the affected eye.

  • Eye Pain: Persistent pain in or around the eye.

  • Light Sensitivity: Increased sensitivity to light (photophobia).

  • Blurred Vision: Vision may become blurry or hazy.

  • Floaters: Small, dark spots or lines that float across the field of vision.

  • Decreased Vision: Partial or complete loss of vision in severe cases.


If you experience any of these symptoms, it is important to seek prompt medical attention from an eye care professional.



Diagnosis of Uveitis
Diagnosing uveitis involves a thorough eye examination and medical history review. Diagnostic tests may include:

  • Slit-Lamp Examination: Allows the doctor to examine the inside of the eye under high magnification.

  • Fundoscopy: Examines the back of the eye, including the retina and optic nerve.

  • Ocular Pressure Test: Measures the pressure inside the eye to check for glaucoma.

  • Blood Tests: Help identify underlying infections or autoimmune diseases.

  • Imaging Tests: Ultrasound, fluorescein angiography, or optical coherence tomography (OCT) may be used to assess the extent of inflammation and damage.



Complications of Uveitis
If left untreated or inadequately managed, uveitis can lead to several serious complications, including:

1. Glaucoma

  • Increased intraocular pressure can damage the optic nerve, leading to vision loss.


2. Cataracts

  • Inflammation can cause clouding of the eye’s lens, leading to cataracts.


3. Macular Edema

  • Swelling of the macula, the central part of the retina, can result in severe vision impairment.


4. Retinal Detachment

  • Inflammation can cause the retina to pull away from the back of the eye, leading to potential blindness if not treated promptly.


5. Permanent Vision Loss

  • Chronic or severe uveitis can cause irreversible damage to eye structures, resulting in permanent vision loss.



Treatment Options for Uveitis
The primary goal of uveitis treatment is to reduce inflammation, alleviate pain, and prevent complications. Treatment options vary depending on the cause, type, and severity of the inflammation.


1. Medications

  • Anti-inflammatory eye drops, oral medications, or injections are commonly used to reduce inflammation.


Immunosuppressive Drugs:

  • For severe or chronic cases, medications that suppress the immune system, such as methotrexate or cyclosporine, may be prescribed.


Antimicrobial Drugs:

  • If an infection is the underlying cause, appropriate antibiotics, antivirals, or antifungals will be prescribed.


2. Surgical Interventions

  • Surgical removal of the vitreous gel from the eye may be necessary in severe cases to reduce inflammation or treat complications.


Glaucoma Surgery:

  • Procedures to reduce intraocular pressure may be required if glaucoma develops.


3. Lifestyle and Home Remedies
Eye Hygiene:

  • Keeping the eyes clean and avoiding rubbing or touching them can help reduce irritation.


Wearing Sunglasses:

  • Sunglasses can help reduce light sensitivity and protect the eyes from UV rays.


Regular Follow-Up:

  • Regular check-ups with an eye care professional are crucial for monitoring the condition and adjusting treatment as needed.


Uveitis is a serious eye condition that requires prompt diagnosis and appropriate treatment to prevent complications and preserve vision. Understanding the causes, symptoms, and potential complications can help individuals seek timely medical attention and adhere to their treatment plans. If you experience any symptoms of uveitis, consult an eye care professional immediately for a comprehensive evaluation and personalized treatment plan.

For more information on eye health and to schedule an eye exam at Hillside Optometry in Granada Hills, call us at 818-474-2020, 

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